Due to their strong interaction with matter and the fact that electrons can be easily focused into a small spot, they are ideal for investigating nano- and microcrystals. Compared to X-rays, the greatly reduced radiation damage effects allow electron diffraction experiments (ED experiments) to obtain considerably more structural information, such as higher resolution, from a single crystal. A major advantage of using high-energy electrons is that, in addition to extremely small crystals of less than 100 nm, crystals with thicknesses of 1–2 micrometers can also be examined, for which sample preparation is relatively simple under a light microscope. REGAE's microbeam mode is particularly well suited for the investigation of nano- and microcrystals.